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AY 77
CAS No. 1835734-92-3
AY 77( —— )
Catalog No. M35259 CAS No. 1835734-92-3
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1043 | Get Quote |
|
| 5MG | 1406 | Get Quote |
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| 10MG | 1891 | Get Quote |
|
| 25MG | 2723 | Get Quote |
|
| 50MG | 3671 | Get Quote |
|
| 100MG | 4851 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAY 77
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NoteResearch use only, not for human use.
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Brief DescriptionAY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).
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DescriptionAY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetPAR
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RecptorProtease-activated Receptor | Calcium Channel | ERK
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Research Area——
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Indication——
Chemical Information
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CAS Number1835734-92-3
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Formula Weight404.5
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Molecular FormulaC21H32N4O4
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Purity>98% (HPLC)
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Solubility——
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SMILES[C@H](CC1CCCCC1)(C(N[C@H](C(N)=O)[C@@H]2CCCCC2)=O)NC(=O)C3=CC=NO3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kl?sel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323.?
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